Just one convenient, daily dose lasts up to 24 hours and can help improve your horse's mobility. Store below 86°F (30°C). The recommended dosage of Equioxx Tablets is one 57 mg tablet administered orally to horses weighing 800-1,300 lbs, once daily for up to 14 days. Slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate 50 lb weight notch. Consult a physician in case of accidental ingestion by humans. In order to maintain a painfree life for my aging mare, I must provide a regimen of both over-the-counter products, as well as the medication, Equioxx. See Information for Owner or Person Treating Horse section of this package insert. Equioxx provides consistent pain relief associated with equine OA (also called degenerative joint disease) for 24 hours with just one daily dose. Your veterinarian may want to check that all of your horse's medicines can be given together. Thirty-two clinically healthy adult horses received Equioxx Injection intravenously once daily for five days at doses of either 0 mg/kg (control group); 0.09 mg/kg (1X); 0.27 mg/kg (3X); or 0.45 mg/kg (5X the recommended dose). This sheet provides a summary of information about Equioxx paste and general information about NSAIDs. Horses treated with Equioxx Oral Paste showed improvement in veterinarian-assessed lameness, pain on manipulation, range of motion, and joint swelling that was comparable to the active control. All medicines that you are giving or plan to give to your horse, including those you can get without a prescription and any dietary supplements. For ease of administration, EQUIOXX … The safety of firocoxib tablets is inferred based on demonstrated comparable relative bioavailability to the oral paste formulation. Gastric ulcers of the margo plicatus and glandular area were more prevalent in the 2.5× and 7.5× groups, but not seen in the 12.5× group. Non-steroidal anti-inflammatory drug for oral use in horses only. Sensitivity to drug-associated adverse events varies with the individual patient. The safety of firocoxib in horses was demonstrated in target animal safety studies and field studies conducted for the registration of the oral paste and injectable equine products. Has had an allergic reaction to firocoxib, the active ingredient in Equioxx. Each marking on the syringe will treat 250 pounds of body weight, and each notch corresponds to approximately a 50 lb weight increment. Since many NSAIDs possess the potential to produce gastrointestinal ulcerations and/or gastrointestinal perforation, concomitant use of Equioxx Tablets with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. Each marking on the syringe will treat 250 lbs of body weight, and each notch corresponds to approximately a 50 lb weight increment. If an overdose is suspected, contact your veterinarian immediately. Had him in wedge pad with shoes on front, and gave Equioxx … Equioxx is available in packs of 20 individually-boxed syringes and packs of 72 individually wrapped syringes. Treatment with Equioxx should be terminated if signs such as inappetance, colic, abnormal feces, or lethargy are observed. In controlled field studies, 127 horses (ages 3 to 37 years) were evaluated for safety when given Equioxx Oral Paste at a dose of 0.045 mg/lb (0.1 mg/kg) orally once daily for up to 14 days. Excellent price on this product with their discount. Brief excursions up to 104°F (40°C) are permitted. Despite a high rate of plasma protein binding (98%), firocoxib exhibits a large volume of distribution (mean Vd(ss) = 1652 mL/kg). It is the only NSAID allowed for use up to 14 days. The majority of patients with drug-related adverse reactions recover when the signs are recognized, drug administration is stopped, and veterinary care is initiated. Following oral administration, drug peak concentration (Cmax) of 0.08 mcg/mL can be reached at 4 hours (Tmax) post-dosing. As with all prescribed medicines, Equioxx paste should only be given to the horse for which it is prescribed. We both thank you for keeping her happy and comfortable! It should be given to your horse only for the condition for which it is prescribed, at the labeled dose and duration. The recommended dosage of Equioxx (firocoxib) for oral administration in horses is 0.045 mg/lb (0.1 mg/kg) of body weight once daily for up to14 days. Administration of firocoxib at 0.1, 0.3 and 0.5 mg/kg body weight was associated with delayed healing of pre-existing oral (lip, tongue, gingival) ulcers. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Two hundred fifty-three client-owned horses of various breeds, ranging in age from 2 to 37 years and weighing from 595 to 1638 lbs, were randomly administered Equioxx Oral Paste or an active control drug in multi-center field studies. Equioxx is a coxib class NSAID that targets COX-2 (cyclooxygenase-2), which help the chemicals responsible for pain and inflammation, while sparing COX-1 (cyclooxygenase-1), which help maintain normal bodily functions like blood flow to the kidneys and gastric mucosal protection. The recommended dosage of Equioxx Tablets is one 57 mg tablet administered orally to horses weighing 800-1,300 lbs, once daily for up to 14 days. Clinical chemistry and coagulation abnormalities were seen in several horses in the 0.5 mg/kg (5×) group. All Rights Reserved. Simparica (sarolaner) Chewables Tablets for Dogs, Senergy (selamectin) Topical Parasiticide for Dogs & Cats, Seresto Flea & Tick Collar for Cats & Dogs, Advantage II Flea Control for Cats and Kittens, Nutramax Dasuquin Joint Supplement for Dogs & Cats, Banamine Paste - SINGLE Syringe 1500mg (30 gm) (Manufacturer may vary), FluMeglumine 50mg/ml Injectable 100ml (Manufacturer may vary), Optimmune Ophthalmic Ointment for Dogs 3.5 gm, Vetmedin (Pimobendan) Chewable Tablets for Dogs, Adequan i.m. Therefore, drug accumulation occurs with repeated dose administrations and steady state concentrations are achieved beyond 6-8 daily oral doses in the horse. Your horse should not be given Equioxx if it: As a general rule, neither Equioxx nor other NSAIDs should be used in conjunction with other NSAIDs (for example, aspirin, phenylbutazone, diclofenac, ketoprofen or flunixin) or systemic corticosteroids (for example, prednisone, cortisone, dexamethasone or triamcinolone). Horses should undergo a thorough history and physical examination before initiation of NSAID therapy. Another 5X male had a similar mild increase in creatinine during the study but did not have any gross abnormal findings. Serious adverse reactions associated with this drug class can occur without warning and, in some situations, result in death. Equioxx is not for use in horses intended for human food consumption. Treatment with Equioxx should not exceed 14 days. If you have additional questions about possible side effects, talk with your veterinarian or call 1-877-217-3543. If you liked this blog, please subscribe below, and share it with … Do not exceed 14 days of treatment. Equioxx Oral Paste was rated both convenient to administer (95.3%) and acceptable to the horse (97.6%) by owners in the multi-center field study. Equioxx can be given with or without food. The group of horses that were monitored until Days 147-149 showed partial to full recovery from oral and skin ulcers, but no recovery from tubulointerstitial nephropathy. Tubulointerstitial nephropathy occurred in one 3X female, two 3X male horses, and the 5X female horse discussed above with the prolonged BMBT. So much easier than mixing butte. Tell your veterinarian if your pet has a known hypersensitivity to firocoxib or other NSAIDs. Always provide the Client Information Sheet with the prescription. Horses that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Equioxx Tablets are administered once daily for up to 14 days for the control of pain and inflammation associated with osteoarthritis in horses. Clients should be advised to observe for signs of potential drug toxicity and be given a Client Information Sheet with each prescription. Is presently taking aspirin, phenylbutazone, flunixin meglumine, diclofenac, ketoprofen, or other NSAIDs or corticosteroids. These consisted of ulcers of the lips, gingiva and tongue and erosions of the skin of the mandible and head. Your horse should not be given Equioxx if he/she: Equioxx paste should only be given orally to horses. Equioxx® (firocoxib) belongs to the coxib class of non-narcotic, non-steroidal anti-inflammatory drugs. Two hundred fifty-three client-owned horses of various breeds, ranging in age from 2 to 37 years and weighing from 595 to 1638 lbs, were randomly administered Equioxx or an active control drug in multi-center field studies. For all horses, these hepatic enzyme elevations generally returned to the reference range by the next time point. Dose linearity exists from 1×-2× of 0.1 mg/kg/day. People should not take Equioxx. Drug compatibility should be monitored in patients requiring adjunctive therapy. The influence of concomitant drugs that may inhibit the metabolism of Equioxx Oral Paste has not been evaluated. Keeps the senior horse joints more comfortable. The majority of patients with drug-related adverse reactions recover when the signs are recognized, drug administration is stopped, and veterinary care is initiated. Appropriate laboratory tests should be conducted to establish hematological and serum biochemical baseline data before and periodically during administration of any NSAID. Sores, scabs, redness, or rubbing of the facial skin, particularly around the mouth. Has previously had an allergic reaction (such as hives, facial or lower limb swelling, or red or itchy skin) to aspirin or other NSAIDs.
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